Some people (life coach and 2 psychiatrists recommended me Zoloft) for feeling better and to help make improvements since I’m struggling with anxiety (especially social anxiety, which can be a problem in work environment). Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Zoloft has an average rating of 7.3 out of 10 from a total of 2,009 reviews on Drugs.com. 64% of reviewers reported a positive experience, while 18% reported a negative experience. Lexapro and Zoloft are both SSRI antidepressants that increase serotonin. They differ in approved conditions but are both generally effective for treating depression. Both can cause side effects like sexual dysfunction, nausea, and sweating. My psychiatrist and I have done an evaluation and think I'm ready to transition from the Zoloft to just taking a stronger dose of Wellbutrin (I want to lose the weight I gained and feel sexual more often) but the Zoloft overall was great even with the side effects. I have been taking zoloft since the mid 1990s. They started me on a low dose. It did take several weeks for it to be effective. I have periodically tapered off and resumed it. I have had no side effects. I am currently taking 150 mg/day with no problems. If has been a life saver for me. Sertraline User Reviews & Ratings Brand names: Zoloft Sertraline has an average rating of 7.3 out of 10 from a total of 4,686 reviews on Drugs.com. 64% of reviewers reported a positive experience, while 18% reported a negative experience. Read 3453 user reviews of Sertraline (Zoloft). Average rating: 3.7/5 for effectiveness, ease of use, and satisfaction. I’m currently in my first month of taking sertraline – an antidepressant commonly prescribed for people starting out. I will be discussing how it’s been making me feel! A community for people taking Zoloft (sertraline) to discuss questions, concerns, and success stories. Zoloft is an antidepressant and anti-anxiety medication in the pharmaceutical class SSRI.